This is an excellent article from The Cell Journal on a study in Nature. This will not surprise most people following Ray Peat's writings, but definitely an eye-opener for the general public (if they ever even become aware of this publication, considering no popular press outlet covered this article). 

Namely, not only are Poly Unsaturated Fatty Acids (PUFA) (which is most seed oils) responsible for the formation of non-alcoholic fatty liver disease (NAFLD) (30%+ of people in the US have that condition), but also its progression to the more severe nonalcoholic steatohepatitis (NASH), and the final descent into cirrhosis and liver cancer (HCC). In other words, linoleic acid (LA) is a liver carcinogen and is entirely sufficient to cause by itself the entire liver disease spectrum. 

Also, the studies show that both LA peroxidation, as well as its "normal" oxidation contribute to liver pathologies. In contrast, none of other tested fatty acids - the monounsaturated (MUFA) oleic or saturated (SFA) palmitic or stearic - were fattening for the liver or caused progression into liver cancer. So, another way to state this finding is that only PUFA is hepatotoxic and carcinogenic. 

Another interesting takeaway from the article is that the progression of fatty liver to HCC is driven by the death/apoptosis of immune cells, which linoleic acid potently induces. So, PUFA is also a potent immuno-suppressor and as such it has relevance for many other diseases, including infectious ones. 

Since the general population is eating, on average, 15g-20g PUFA daily this amounts to a daily immunosuppressive regimen rivaling the effects of chronic glucocorticoid therapy. PUFA also activates the HPA axis and leads to chronically elevated glucocorticoids as well - i.e. a doubly immunosuppressive effect. 

In light of this population-wide dietary "immune suicide", it is little wonder immune related diseases are much more prevalent today and are much more lethal than in the past. The good news is that the blockage of free radical formation triggered by LA was fully preventable by administration of an anti-oxidant, so combining a daily dose of Superoxide Dismutase with Catalase found in Youthxym and taking 200 IU vitamin E daily, in the form of E-Mulsion would a good idea.
 

Original article by Georgi Dinkov

Modified by Stephen Heuer